Dual mechanisms diminishing tonic GABAA inhibition of 1 dentate gyrus granule cells in Noda epileptic rats
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چکیده
29 The Noda epileptic rat (NER), a Wistar colony mutant, spontaneously has tonic– 30 clonic convulsions with paroxysmal discharges. In the present study, we measured 31 phasic (I phasic) and tonic γ-aminobutyric acid A (GABA A) current (I tonic) in NER 32 hippocampal dentate gyrus granule cells (DGGCs) and compared the results with 33 those of normal parent strain Wistar rats (WIS).
منابع مشابه
Dual mechanisms diminishing tonic GABAA inhibition of dentate gyrus granule cells in Noda epileptic rats.
The Noda epileptic rat (NER), a Wistar colony mutant, spontaneously has tonic-clonic convulsions with paroxysmal discharges. In the present study, we measured phasic and tonic γ-aminobutyric acid A (GABAA) current (I tonic) in NER hippocampal dentate gyrus granule cells and compared the results with those of normal parent strain Wistar rats (WIS). I tonic, revealed by a bicuculline-induced outw...
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